Transcriptional Mechanisms of Drug Addiction
نویسندگان
چکیده
منابع مشابه
Transcriptional Mechanisms of Drug Addiction
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription factors, proteins that bind to regulatory regions of specific genes and thereby control levels of their expression, have been implicated in the addiction process over the past decade or two. Here we review the g...
متن کاملMolecular mechanisms of drug addiction.
Regulation of gene expression is one mechanism by which drugs of abuse can induce relatively long-lasting changes in the brain to cause a state of addiction. Here, we focus on two transcription factors, CREB (cAMP response element binding protein) and DeltaFosB, which contribute to drug-induced changes in gene expression. Both are activated in the nucleus accumbens, a major brain reward region,...
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Regulation of gene expression is considered a plausible mechanism of drug addiction, given the stability of behavioural abnormalities that define an addicted state. Among many transcription factors known to influence the addiction process, one of the best characterized is DFosB, which is induced in the brain’s reward regions by chronic exposure to virtually all drugs of abuse and mediates sensi...
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Drug addiction is believed to be a chronic and convertible disease resulting in the obtrusive aim of drugs ingestion and the use of them in spite of health risk and life threat. Human behavior is mainly a resultant force of 3 actions of the functional CNS: arousal, reward and cognition. In addition all of them are advanced in the development of drug addiction. For the proper functioning of ever...
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ژورنال
عنوان ژورنال: Clinical Psychopharmacology and Neuroscience
سال: 2012
ISSN: 1738-1088,2093-4327
DOI: 10.9758/cpn.2012.10.3.136